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LncRNA AC098613.1 promotes acute myeloid leukemia cell differentiation through CDC5L/ADAP1/NRD1 axis

GSE316435 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2026/02/03 Platform GPL24676
Summary
In this study, ATRA and PMA were employed to induce THP-1 cell differentiation, and whole transcriptome sequencing was used to screen out the significantly differentiated expression of lncRNAs during AML cell differentiation. Further, we found that AC098613.1 was significantly upregulated in differentiated AML cells, while AC098613.1 overexpression significantly promoted the differentiation of THP-1 and HL-60 cells. Therefore, the mechanism of AC098613.1-induced AML cell differentiation and the tumor-suppressive effect of AC098613.1 in vivo were further investigated.
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Also filed as BioProject PRJNA1402899 and SRA study SRP662136. Searching any of these in the dataset finder brings you back here.

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