POFUT1 Serves as an Independent Prognostic Factor and Therapeutic Target by Activating the PI3K/AKT Pathway in Glioma
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 14 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE316535_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1403273 and SRA study SRP662837. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 14 sample titles: 14 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9455483 U251NC_r1(negative control about OE,repeat1)
- GSM9455484 U251NC_r2(negative control about OE,repeat2)
- GSM9455485 U251OE_r1(POFUT1OE,repeat1)
- GSM9455486 U251OE_r2(POFUT1OE,repeat2)
- GSM9455487 U251OE_r3(POFUT1OE,repeat3)
- GSM9455488 U251SiNC_r1(negative control about Si,repeat1)
- GSM9455489 U251SiNC_r2(negative control about Si,repeat2)
- GSM9455490 U251SiNC_r3(negative control about Si,repeat3)
- GSM9455491 U251Si_r1(POFUT1Si,repeat1)
- GSM9455492 U251Si_r2(POFUT1Si,repeat2)
- GSM9455493 U251Si_r3(POFUT1Si,repeat3)
- GSM9455494 U251_r1(Parent cell,repeat1)
- GSM9455495 U251_r2(Parent cell,repeat2)
- GSM9455496 U251_r3(Parent cell,repeat3)
- GSE269369 LIN28B-mediated activation of the PI3K/AKT pathway promotes metastasis and unravels a new therapeutic vulnerability in colorectal cancer 18 samples shares pi3k, akt, therapeutic
- GSE333995 IGFBP5 Derived From Endothelial Cells Drive Vascular Invasion and Liver Metastasis of Colorectal Cancer by Activating the ITGB3/PI3K/AKT Axis 9 samples shares pi3k, akt, activating
- GSE316568 MiR-424-5p Acts as an Oncogene in Hep3B Cells by Activating the PI3K/AKT Signaling Pathway 12 samples shares pi3k, akt, activating
- GSE317889 Combined DNA and RNA profiling refines prognostic stratification independent of therapeutic actionability in cholangiocarcinoma 62 samples shares independent, therapeutic, prognostic
- GSE260759 Targeting a Lineage-Specific PI3Kɣ/AKT Signaling Module in Acute Myeloid Leukemia Using a Heterobifunctional Degrader Molecule 24 samples shares pi3k, akt
- GSE322525 PI3K-AKT activation determines oncogenic RAS-induced hypertranscription and replication stress [RNASeq] 18 samples shares pi3k, akt
- GSE241046 miR-BART1-3p inhibits proliferation and invasion of gastric cancer cells by regulating STAT3/pSTAT3 and PI3K/AKT/pAKT signaling pathways 12 samples shares pi3k, akt
- GSE338020 Sturgeon Cartilage–Derived Peptides Promote Cartilage Repair-Associated Responses in Osteoarthritis via Integrin αvβ3–PI3K/Akt Signaling 12 samples shares pi3k, akt
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.