Sturgeon Cartilage–Derived Peptides Promote Cartilage Repair-Associated Responses in Osteoarthritis via Integrin αvβ3–PI3K/Akt Signaling
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 4 × Con vs 4 × MO vs 4 × SCPGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE338020_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1492117 and SRA study SRP716410. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9864685 Con_1 Con
- GSM9864686 Con_2 Con
- GSM9864687 Con_3 Con
- GSM9864688 Con_4 Con
- GSM9864689 MO_1 MO
- GSM9864690 MO_2 MO
- GSM9864691 MO_3 MO
- GSM9864692 MO_4 MO
- GSM9864693 SCP_1 SCP
- GSM9864694 SCP_2 SCP
- GSM9864695 SCP_3 SCP
- GSM9864696 SCP_4 SCP
- GSE286154 TL1A(TNFSF15)-ENO1 axis promotes osteoarthritis by disrupting redox homeostasis via the PI3K/AKT pathway[II] 16 samples shares pi3k, osteoarthritis
- GSE333995 IGFBP5 Derived From Endothelial Cells Drive Vascular Invasion and Liver Metastasis of Colorectal Cancer by Activating the ITGB3/PI3K/AKT Axis 9 samples shares pi3k, derived
- GSE253170 Effect of PI3K/mTOR dual-target inhibitor WX390 on adipose-derived stem cells isolated from facial infiltrating lipomatosis 6 samples shares pi3k, derived
- GSE290045 Colorectal cancer-derived osteopontin rewires macrophages into a pro-metastatic M2 state via the PI3K/AKT/CSF1-CSF1R axis 6 samples shares pi3k, derived
- GSE293777 A high-risk osteoarthritis mutation in COL6A3 alters the mechanobiologic response of chondrocytes derived from human induced pluripotent stem cells 84 samples shares osteoarthritis, derived
- GSE114007 Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis 38 samples shares osteoarthritis, cartilage
- GSE275825 Transcriptome analysis of human embryonic stem cell-derived cartilage pellets at three stages of differentiation 14 samples shares cartilage, derived
- GSE279915 Complexity of synovial fluid-derived monocyte–macrophage lineage cells in knee osteoarthritis 12 samples shares osteoarthritis, derived
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.