GEO series
Sturgeon Cartilage–Derived Peptides Promote Cartilage Repair-Associated Responses in Osteoarthritis via Integrin αvβ3–PI3K/Akt Signaling
GSE338020
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/07/08
GPL29480
Summary
Osteoarthritis (OA) features progressive cartilage loss with no effective regenerative therapies. This study investigated sturgeon cartilage peptides (SCPs) for OA repair and identified key bioactive peptides and mechanisms. SCPs, prepared by trypsin hydrolysis, were evaluated in in vitro and in vivo OA models. SCPs markedly improved cartilage damage, reduced matrix degradation, and increased chondrocyte proliferation to 126%.
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