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Immune cell kinetics during Th17 adoptive trasfer-mediated experimental autoimmune encephalomyelitis

GSE316626 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/05/15 Platform GPL21493
Summary
This study sought to characterive the spatial and temporal differences in comprehensive mononuclear immune cells throughout the disease course in a preclinical mouse model of central nervous system (CNS) autoimmune demyelinating disease. This dataset allows for the identification of transcriptionally distinct immune cell subsests within more general populations, inlcuding monocytes, neutrophils, microglia, T cells, and B cells, that are present in the blood and spinal cord during disease.
Published in
Alternatively activated neutrophils limit T cell-driven neuroinflammation
Atkinson JR, Bellinger C, Jerome AD et al. · Journal of neuroinflammation 2026 · PMID 41896962 · doi:10.1186/s12974-026-03780-9
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Direct links to NCBI, no account and no request form: the whole study as GSE316626_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1403502 and SRA study SRP662803. Searching any of these in the dataset finder brings you back here.

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