GEO series
Total RNA-seq of C2C12 myotubes treated with agrin or MuSK antibodies
GSE316686
Mus musculus
Expression profiling by high throughput sequencing
20 samples
2026/01/20
GPL24247
Summary
Total RNA-seq was performed to investigate if MuSK antibody binding directly affects (NMJ) gene expression in muscle cells. C2C12 differentiated myotubes were treated for 16 hours with bivalent MuSK antibodies (activating MuSK signaling) or functionally monovalent MuSK antibodies (inhibiting agrin-induced MuSK signaling) derived from B-cell receptor sequences from a MuSK myasthenia gravis patient. The total RNA transcriptome was compared to treatment with agrin (the natural activator of MuSK) or a negative control antibody targeting a protein not present in myotubes.
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Paper (PMID 42391746) ↗
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