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Transcriptomic analysis of cold-acclimated D10 T cells

GSE316736 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/15 Platform GPL34290
Summary
T cells are highly sensitive to temperature changes, and low temperatures markedly affect their motility and functional behavior. In this study, we performed RNA sequencing to investigate transcriptomic changes associated with cold acclimation in T cells. D10 CD4⁺ helper T cells were cultured at either 37°C or cold-acclimated at 26°C for 24 hours, followed by RNA extraction and high-throughput sequencing. Comparative transcriptomic analysis was conducted to identify genes and biological pathways regulated by cold acclimation. This dataset provides a resource for understanding molecular responses of T cells to sustained low-temperature exposure.
Published in
Adaptive restoration of T-cell motility by cold acclimation through metabolic and transcriptional remodeling
Hattori M, Onishi N, Sato T et al. · Frontiers in immunology 2026 · PMID 42099603 · doi:10.3389/fimmu.2026.1789182
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Also filed as BioProject PRJNA1404103 and SRA study SRP663462. Searching any of these in the dataset finder brings you back here.

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