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Transcriptomic profiling of wild-type and TigarKO mouse hearts [RNA-Seq]

GSE317048 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/01/30 Platform GPL17021
Summary
Myocardial infarction induces profound transcriptional remodeling in the heart, particularly affecting mitochondrial pathways. To characterize zone-specific transcriptomic responses, we performed RNA sequencing of infarct, border, and remote regions from wild-type (WT) and TKO mouse hearts following infarction. Analysis of infarct territories revealed extensive preservation of mitochondrial gene expression in TKO hearts compared with WT controls. In contrast, mitochondrial DNA–encoded gene expression showed no significant differences between WT and TKO hearts in either the border or remote zones. Similarly, expression of nuclear-encoded genes in the border and remote zones was largely unchanged between genotypes. Together, these data indicate that transcriptional differences between WT and TKO hearts are predominantly localized to the infarct region, while border and remote zones exhibit minimal genotype-dependent changes.
Published in
TIGAR deficiency enhances cardiac resilience through epigenetic programming of Parkin expression
Tang Y, Jankauskas SS, Liu L et al. · JCI insight 2026 · PMID 41746736 · doi:10.1172/jci.insight.200105
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Also filed as BioProject PRJNA1405706 and SRA study SRP664834. Searching any of these in the dataset finder brings you back here.

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