Wnt Activation and Dual SMAD Inhibition For Induction and Maintenance of Hindbrain-like Neural Stem Cell from hiPSCs [RNA-Seq]
RNA-seq (gene expression) · human · 23 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 23 samples: 10 × iNSCs_PN vs 3 × ACL_P0D7 vs 2 × ACL_iNSCs_PN vs 2 × ACL_PN5Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Wnt activation and dual SMAD inhibition for induction and maintenance of hindbrain-like neural stem cell from hiPSCsCell reports methods · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE317319_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1406739 and SRA study SRP665647. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 17 samples.
How we read this: 4 replicated groups read from 23 sample titles; they account for 17 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9469224 ACL_iNSCs_PN5 ACL_iNSCs_PN
- GSM9469225 ACL_iNSCs_PN60 ACL_iNSCs_PN
- GSM9469226 ACLiNSCs_PN5_Diff2D
- GSM9469227 ACLiNSCs_PN61_Diff2D
- GSM9469228 ACL_P0D7_1 ACL_P0D7
- GSM9469229 ACL_P0D7_2 ACL_P0D7
- GSM9469230 ACL_P0D7_3 ACL_P0D7
- GSM9469231 ACL_PN5_2 ACL_PN5
- GSM9469232 ACL_PN5_3 ACL_PN5
- GSM9469233 ACL_PN60
- GSM9469234 ACL_PN60_3
- GSM9469235 HLA_ACL_iNSCs_PN5
- GSM9469236 iNSCs_PN10 iNSCs_PN
- GSM9469237 iNSCs_PN15 iNSCs_PN
- GSM9469238 iNSCs_PN20 iNSCs_PN
- GSM9469239 iNSCs_PN25 iNSCs_PN
- GSM9469240 iNSCs_PN30 iNSCs_PN
- GSM9469241 iNSCs_PN35 iNSCs_PN
- GSM9469242 iNSCs_PN40 iNSCs_PN
- GSM9469243 iNSCs_PN45 iNSCs_PN
- GSM9469244 iNSCs_PN50 iNSCs_PN
- GSM9469245 iNSCs_PN55 iNSCs_PN
- GSM9469246 SgT5-2_ACL_iNSCs_PN5
- GSE294699 Loss of H3K9me3 maintenance leads in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons 12 samples shares maintenance, activation, neural
- GSE341139 A conserved HAND2-BMP5-SMAD1/5/9 axis drives hepatic stellate cell activation and extracellular matrix overproduction in multiple fibrotic etiologies 10 samples shares smad, activation
- GSE341616 A conserved HAND2-HAND2_OE-SMAD1/5/9 axis drives hepatic stellate cell activation and extracellular matrix overproduction in multiple fibrotic etiologies 5 samples shares smad, activation
- GSE254732 Inhibition of PCSK9 with evolocumab modulates lipoproteins and monocyte activation in high-risk ASCVD subjects 215 samples shares activation, inhibition
- GSE327289 Cerebrovascular Single-Nucleus RNA-Seq Reveals Heat Shock Activation and Vascular Remodeling in Alzheimer’s Disease and Primary Tauopathies 76 samples shares activation, rna-seq
- GSE295260 CDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activation 40 samples shares activation, inhibition
- GSE304579 Alternative End-Joining Activation by miR-21-5p Confers Radiation Resistance in Oral Squamous Cell Carcinoma [RNA-seq of SUGH-OSCC patient tumors] 34 samples shares activation, rna-seq
- GSE337839 CRISPR activation of DLX5 drives neural progenitors to the GnRH cell fate 29 samples shares activation, neural
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.