Identification of CD74-positive antigen presenting glioma cells in primary human tumors and murine models of NF1 high-grade glioma
Single-nucleus RNA-seq · mouse · 10 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 3 × NF1 HGG17 Allo Nf1 vs 3 × NF1 HGG17 Allo wtGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Identification of CD74-positive antigen presenting glioma cells in primary human tumors and murine models of NF1 high-grade gliomaMolecular cancer therapeutics · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE317486_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1413414 and SRA study SRP666028. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9472964 NF1 HGG17 Allo Nf1 Rep1 NF1 HGG17 Allo Nf1
- GSM9472965 NF1 HGG17 Allo Nf1 Rep2 NF1 HGG17 Allo Nf1
- GSM9472966 NF1 HGG17 Allo Nf1 Rep3 NF1 HGG17 Allo Nf1
- GSM9472967 NF1 HGG17 Allo wt Rep1 NF1 HGG17 Allo wt
- GSM9472968 NF1 HGG17 Allo wt Rep2 NF1 HGG17 Allo wt
- GSM9472969 NF1 HGG17 Allo wt Rep3 NF1 HGG17 Allo wt
- GSM9472970 Mock Nf1 het
- GSM9472971 Mock wt
- GSM9472972 NF1 HGG17 In Vitro GEX Pool
- GSM9472973 NF1 HGG17 In Vitro CMO Pool
- GSE274163 Primary murine high-grade glioma cells derived from RCAS/tv-a diffuse glioma model reprogram naïve T cells into immunosuppressive regulatory T lymphocytes. 8 samples shares high-grade, primary, glioma
- GSE295070 Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially regulate T-cell phenotype and function 5 samples shares presenting, antigen
- GSE325923 Intratumoral CD40 agonist sotigalimab in combination with pembrolizumab induces rapid activation of antigen presenting cells and drives anti-tumor responses in non-injected tumors in metastatic melanoma: Results of a phase 1/2 study 4 samples shares presenting, antigen
- GSE103618 Direct reprogramming of fibroblasts into antigen-presenting dendritic cells 221 samples shares presenting, antigen
- GSE247864 Capmatinib shows superior efficacy for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy [RNA-seq] 36 samples shares high-grade, glioma
- GSE255971 The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models [RNA-seqII] 12 samples shares high-grade, glioma
- GSE61462 Delineating Tumor-infiltrating Antigen Presenting Cell populations 12 samples shares presenting, antigen
- GSE241945 ILC2s directly activate anti-tumor cytotoxic CD8+ T lymphocytes by internalizing, processing, and presenting exogenous antigens 8 samples shares presenting, antigen
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.