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The role of BAF60C in type 2 diabetes ——ATAC-seq

GSE317708 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/02/06 Platform GPL21103
Summary
This research identify reduced expression of BAF60C in diabetic islets and demonstrate that altered β-cell BAF60C levels strongly influence metabolic homeostasis. Genetic loss of BAF60C in β-cells exacerbates hyperglycemia and islet dysfunction under metabolic stress, whereas β-cell–specific restoration of BAF60C produces protective effects. These findings establish BAF60C as an important regulator of β-cell integrity and disease progression in T2D.
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Also filed as BioProject PRJNA1414946 and SRA study SRP667632. Searching any of these in the dataset finder brings you back here.

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