GEO series
The role of BAF60C in type 2 diabetes——RNAseq
GSE317978
Mus musculus
Expression profiling by high throughput sequencing
25 samples
2026/02/06
GPL23479
Summary
This research identify reduced expression of BAF60C in diabetic islets and demonstrate that altered β-cell BAF60C levels strongly influence metabolic homeostasis. Genetic loss of BAF60C in β-cells exacerbates hyperglycemia and islet dysfunction under metabolic stress, whereas β-cell–specific restoration of BAF60C produces protective effects. These findings establish BAF60C as an important regulator of β-cell integrity and disease progression in T2D.
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