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Fragmentation through cell-cell adhesion maintains senescent cell viability but promotes debris deposition

GSE317982 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/12 Platform GPL30173
Summary
We identified that senescent cells dispose of large fragments of themselves through cell-to-cell adhesion, which we term senescent-cell adhesion fragments (SCAFs). Dynamic analyses show that SCAFs ultimately rupture, releasing a complex proteome including damage-associated molecular patterns (DAMPs) and proteins linked to neurodegenerative disease. Functionally, SCAFs activate wound-healing and cancer-related programs, promoting migration and invasion.
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Also filed as BioProject PRJNA1416262 and SRA study SRP670207. Searching any of these in the dataset finder brings you back here.

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