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Co-delivery of Cisplatin and Bmi1 siRNA via Nanocapsules Overcomes Chemoresistance in Ovarian Cancer

GSE318061 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/27 Platform GPL16791
Summary
Ovarian Cancer (OC) is one of the gynecological malignancies with the highest mortality rate. Among the numerous subtypes of ovarian cancer, high-grade serous ovarian cancer (HGSOC) is the most common subtype and has a significant impact on prognosis, accounting for approximately 70%-80% of ovarian cancer-related deaths. Platinum-based chemotherapy combined with paclitaxel is the main approach for treating HGSOC. However, up to 75% of patients with advanced HGSOC will experience recurrence and eventually develop platinum-based resistance, among which approximately 20% of patients do not respond to first-line platinum-based treatment initially. Studies have shown that Cancer Stem cells (CSCs) play a key role in chemotherapy resistance of ovarian cancer. Bmi1 is an important protein for maintaining the stemness of tumor cells. Targeting Bmi1 is regarded as an effective treatment strategy for tumor drug resistance.
Published in
Co-delivery of cisplatin and Bmi1 siRNA via nanocapsules overcomes chemoresistance in ovarian cancer
Liu M, Liu X, Heng J et al. · Scientific reports 2026 · PMID 41922680 · doi:10.1038/s41598-026-46162-0
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Also filed as BioProject PRJNA1416408 and SRA study SRP670605. Searching any of these in the dataset finder brings you back here.

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