Peripheral blood mononuclear cells single-cell landscape of newly diagnosed NK/T cell lymphoma patients

Natural killer/T cell lymphoma (NKTCL) is a rare and aggressive form of non-Hodgkin's lymphoma associated with Epstein-Barr Virus (EBV) infection.The recent advancement of multi-omics technologies has significantly enhanced our understanding of NKTCL disease biology, including genetics, transcription landscape, variations of EBV strain, and microenvironments. Emerging evidence suggests that immunoprofiling of peripheral blood mononuclear cells (PBMCs) is associated with the treatment response of cancer patients and can be used to guide clinical trials and therapy. In this study, we utilized single-cell RNA sequencing (scRNA-seq) to comprehensively characterize the phenotypic landscape of PBMCs in newly diagnosed patients with NKTCL. This research offers a valuable peripheral blood-based signature for newly diagnosed NKTCL, which could be a crucial resource for further investigations into the pathogenesis of NKTCL and the optimization of therapeutic regimens.