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Cleavage Under Targets & Release Using Nuclease (CUT&RUN) of monosomy 7 compared to normal karyotype control

GSE318557 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/03/26 Platform GPL15520
Summary
Monosomy 7 is one of the most frequent aneuploidies in myeloid malignancies, associated to heterogeneous phenotypes. Its poor prognosis differentiates it from aberrations leading to partial/complete loss of 7q region. Underlying pathogenic mechanisms are still undetermined. We performed a comprehensive epi-genomic study of karyotypically isolated monosomy 7 in adult Myelodysplastic Syndromes/Acute Myeloid Leukemias.
Published in
A specific stem cell program and CD112 immunological axis dysfunctions underpinning monosomy 7-associated myeloid neoplasms
Lema Fernandez AG, Nardelli C, Quintini M et al. · Signal transduction and targeted therapy 2026 · PMID 42115611 · doi:10.1038/s41392-026-02681-w
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Also filed as BioProject PRJNA1419218 and SRA study SRP674927. Searching any of these in the dataset finder brings you back here.

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