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Sensory neuron dysfunction in dorsal root ganglia during disease onset in the SOD1G93A mouse model for ALS

GSE318631 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/25 Platform GPL24247
Summary
Amyotrophic lateral sclerosis (ALS) is primarily characterized by motor neuron degeneration, but accumulating evidence suggests that sensory neurons are also affected. To investigate early sensory neuron dysfunction in ALS, we performed bulk RNA sequencing of dorsal root ganglia (DRG) isolated from SOD1-G93A transgenic mice and wild-type controls at disease onset. This dataset provides transcriptomic profiles that reveal molecular alterations associated with ALS-related sensory neuron pathology.
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Direct links to NCBI, no account and no request form: the whole study as GSE318631_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1419325 and SRA study SRP675029. Searching any of these in the dataset finder brings you back here.

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