Non-canonical mTORC1-TFEB activation due to loss of TSC1 determines hepatocyte plasticity and drives cholangiocarcinogenesis
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE318879_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1420769 and SRA study SRP675810. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE249979 Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation [RNA-Seq] 12 samples shares non-canonical, plasticity
- GSE250459 Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells [RNA-Seq] 12 samples shares non-canonical, activation
- GSE281427 Non-canonical Hedgehog signaling via GLI2 promotes pancreatic stellate cell activation and fibrosis in chronic pancreatitis 6 samples shares non-canonical, activation
- GSE291395 Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation [SMART-seq] 6 samples shares non-canonical, plasticity
- GSE273795 Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet 6 samples shares non-canonical, activation
- GSE250460 Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells 20 samples shares non-canonical, activation
- GSE250458 Non-canonical roles of Keap1/Nrf2 in regulating quiescence and early activation in adult muscle stem cells [ChIP-Seq] 8 samples shares non-canonical, activation
- GSE277418 Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation [ATAC-seq] 2 samples shares non-canonical, plasticity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.