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Single-cell RNA-seq of human non-lesional whole skin adjacent to an invasive melanoma excision scar, 5cm from the scar biopsy, and at a distant photoprotected site

GSE318899 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/06/09 Platform GPL34281
Summary
Potentially carcinogenic mutations are widespread throughout the skin, and it is unknown why only some sites develop into a malignancy while most others continue to function normally. Using 10x Genomics Chomium Flex scRNA-seq, we explored differences in skin with similar levels of photodamage adjacent to and proximal to (5cm away from) a melanoma excision scar, and distant photoprotected skin.
Published in
The genomic and spatial transcriptomic landscape of seborrheic keratoses
Oey HM, Kao YC, Lee KJ et al. · The Journal of investigative dermatology 2026 · PMID 42413572 · doi:10.1016/j.jid.2026.03.048
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Also filed as BioProject PRJNA1420787 and SRA study SRP675834. Searching any of these in the dataset finder brings you back here.

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