Transcriptomic profiling of neonatal mouse ventricular myocytes (NMVMs) under hypoxia and recombinant Serglycin stimulation

To investigate the direct regulatory effects of Serglycin (SRGN) on cardiomyocytes under ischemic conditions, we performed bulk RNA-sequencing on primary neonatal mouse ventricular myocytes (NMVMs). The study includes three experimental groups: Control (Con), Hypoxia, and Hypoxia + recombinant SRGN (rSRGN). NMVMs in the Hypoxia and Hypoxia+rSRGN groups were subjected to oxygen-glucose deprivation (glucose-free and serum-free DMEM) in an anaerobic environment (AnaeroPack-MIC, Mitsubishi A-07) for 6 hours. This dataset identifies the transcriptional alterations driven by SRGN in cardiomyocytes during hypoxic stress.