GEO series
DNA methylation stochasticity is linked to transcriptional variability and identifies convergent epigenetic disruption across genetically-defined subtypes of AML [PrimaryAML_scATACseq]
GSE319447
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
24 samples
2026/03/09
GPL20301GPL24676
Summary
Epigenetic regulators are frequently mutated in acute myeloid leukemia (AML). We investigated DNA methylation stochasticity in genetic subtypes of AML using WGBS data and publicly-available ERRBS data, and identified transcriptional dysregulation and altered chromatin accessibility related to methylation entropy using single-cell RNA-seq and single-cell ATAC-seq data.
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Paper (PMID 41838954) ↗
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