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Effect of depletion of NAMPT in human endothelial cells (B4G12)

GSE319606 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/10 Platform GPL24676
Summary
In our study, NAMPT was found downregulated In the corneal endothelium of patients with Fuchs endothelial corneal dystrophy. In this study, NAMPT was knocked down in the human corneal endothelial cell line (B4G12), and significant decreases in corneal endothelial cell viability, as well as the activation of immune-related pathways and extracellular matrix remodeling pathways, were observed. These changes are consistent with the expression profile of corneal endothelium in FECD patients, suggesting that downregulation of NAMPT plays an important role in the pathogenesis of FECD.
Published in
NAMPT Deficiency Promotes Endothelial-Mesenchymal Transition by Inhibiting Energy Metabolism and Lysosomal Acidification in Late-Onset Fuchs Endothelial Corneal Dystrophy
Xie L, Chen M, Wu J et al. · Investigative ophthalmology & visual science 2026 · PMID 42206947 · doi:10.1167/iovs.67.5.70
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Also filed as BioProject PRJNA1424717 and SRA study SRP677628. Searching any of these in the dataset finder brings you back here.

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