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RNA-seq of tumors from mice treated with FPC (5-FU, anti-PD-1 antibody, and anti-CTLA-4 antibody), mRNA–LNP and KDM5B inhibitors.

GSE319665 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/01 Platform GPL24247
Summary
Chimeric antigen receptor (CAR) T cell therapy is a highly effective cancer treatment that harnesses immune cells. However, significant challenges remain, particularly with respect to its application to solid tumours and the high cost of manufacturing. To address these limitations, the development of mRNA–lipid nanoparticle (LNP) therapeutics capable of generating CAR-T cells in vivo has attracted increasing attention. In this study, we administered LNP-formulated mRNA encoding a fibroblast activation protein (FAP)-targeting CAR in a mouse tumour model and investigated how tumour-resident cells alter their gene expression profiles in response. We further examined how KDM5B inhibition influences the antitumor effect in combination with in vivo CAR-T therapy.
Published in
Identification of Novel Small-Molecule Inhibitors Targeting KDM5B and Evaluation of Their Antitumour Effects
Hara T, Meng S, Konno M et al. · Cancer medicine 2026 · PMID 42324589 · doi:10.1002/cam4.72058
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Also filed as BioProject PRJNA1424926 and SRA study SRP677705. Searching any of these in the dataset finder brings you back here.

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