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Histotripsy-initiated immune response in a neuroblastoma murine model

GSE319944 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2026/02/18 Platform GPL34281
Summary
High-risk neuroblastoma (NB) is a pediatric malignancy associated with metastases and an immunosuppressive tumor microenvironment. Standard-of-care treatments like chemotherapy are often ineffective, which motivates the investigation of adjuvant approaches. Histotripsy is a noninvasive focused ultrasound therapy that ablates tissue through the mechanical action of bubble clouds. In addition to disruption of the targeted tumor, non-targeted lesions exhibit growth delay after the histotripsy procedure. The primary hypothesis of this study was histotripsy-induced shifts in the tumor microenvironment will improve the response of metastatic NB to chemotherapy.
Published in
Histotripsy-Initiated Immune Response Synergizes with Chemotherapy in a Neuroblastoma Murine Model
Antonides-Jensen N, Singh M, Xue Y et al. · Cancers 2026 · PMID 42073574 · doi:10.3390/cancers18081249
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Also filed as BioProject PRJNA1425563 and SRA study SRP678105. Searching any of these in the dataset finder brings you back here.

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