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Screening of histone modulators small molecule library reveals Kdm5b as a major epigenetically control of cell cycle gene expression in CMs

GSE319947 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 5 samples Submitted 2026/05/13 Platform GPL34290
Summary
In this study, through a small molecule screening, we defined the histone lysine demethylase, Kdm5b, as a major epigenetic driver that controls the CM cell cycle gene expression in neonatal stage and can be reintroduced in adult CMs to induce cell cycle. Mechanistically, RNAseq and CUT&RUN analyses of Kdm5b KD in NMCM P1 revealed that Kdm5b modulates the expression and the enrichment of H3K4me3 methylation around the regulatory regions of the genes involved in cell cycle.
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Also filed as BioProject PRJNA1425577 and SRA study SRP678102. Searching any of these in the dataset finder brings you back here.

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