Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 8 × KDM5b WT vs 8 × KDM5b HomGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiencyScience advances · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE311802_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1370926 and SRA study SRP649734. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9332335 KDM5b WT1 KDM5b WT
- GSM9332336 KDM5b WT2 KDM5b WT
- GSM9332337 KDM5b WT3 KDM5b WT
- GSM9332338 KDM5b WT4 KDM5b WT
- GSM9332339 KDM5b WT5 KDM5b WT
- GSM9332340 KDM5b WT6 KDM5b WT
- GSM9332341 KDM5b WT7 KDM5b WT
- GSM9332342 KDM5b WT8 KDM5b WT
- GSM9332343 KDM5b Hom1 KDM5b Hom
- GSM9332344 KDM5b Hom2 KDM5b Hom
- GSM9332345 KDM5b Hom3 KDM5b Hom
- GSM9332346 KDM5b Hom4 KDM5b Hom
- GSM9332347 KDM5b Hom5 KDM5b Hom
- GSM9332348 KDM5b Hom6 KDM5b Hom
- GSM9332349 KDM5b Hom7 KDM5b Hom
- GSM9332350 KDM5b Hom8 KDM5b Hom
- GSE262555 Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency 16 samples shares nmdar2d, kdm5b, autism-like, demethylase, phenotypes, deficiency, increased, histone
- GSE316882 Autism-like phenotypes and increased NMDAR2D expression in mice with KDM5B histone lysine demethylase deficiency [CUT&Tag] 6 samples shares nmdar2d, kdm5b, autism-like, demethylase, phenotypes, deficiency, increased, histone
- GSE244240 Sex specific role of KDM5B demethylase in Alcohol-associated Liver Disease development and resolution 27 samples shares kdm5b, demethylase
- GSE318762 Screening of histone modulators small molecule library reveals Kdm5b as a major epigenetic modulator of cell cycle gene expression in Cardiomyocyte 6 samples shares kdm5b, histone
- GSE319947 Screening of histone modulators small molecule library reveals Kdm5b as a major epigenetically control of cell cycle gene expression in CMs 5 samples shares kdm5b, histone
- GSE262866 The histone demethylase KDM5C regulates IRF transcriptional programming impacting dendritic cell population heterogeneity and function (RNA-seq) 55 samples shares demethylase, histone
- GSE239950 Effect of KDM5 histone demethylase in 3T3-L1 differentiation 29 samples shares demethylase, histone
- GSE286059 Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants [EU] 24 samples shares demethylase, histone
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.