Effect of pancreatic tumor interstitial fluid media on transcriptional responses in PDAC cells
RNA-seq (gene expression) · human · 54 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Pancreatic cancerThis series is part of our curated briefing on it.
- Samples
- 54 samples: 18 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The HIF-2 transcription factor mediates resistance to ferroptosis in pancreatic cancerMolecular cell · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE319951_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1425608 and SRA study SRP678119. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 54 samples.
How we read this: 18 replicated groups read from 54 sample titles; they account for 54 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9530230 Bon1 Hypoxia Control Replicate 1 Bon1 Hypoxia Control
- GSM9530231 Bon1 Hypoxia Control Replicate 2 Bon1 Hypoxia Control
- GSM9530232 Bon1 Hypoxia Control Replicate 3 Bon1 Hypoxia Control
- GSM9530233 Bon1 Normoxia Control Replicate 1 Bon1 Normoxia Control
- GSM9530234 Bon1 Normoxia Control Replicate 2 Bon1 Normoxia Control
- GSM9530235 Bon1 Normoxia Control Replicate 3 Bon1 Normoxia Control
- GSM9530236 Hep3B Hypoxia Control Replicate 1 Hep3B Hypoxia Control
- GSM9530237 Hep3B Hypoxia Control Replicate 2 Hep3B Hypoxia Control
- GSM9530238 Hep3B Hypoxia Control Replicate 3 Hep3B Hypoxia Control
- GSM9530239 Hep3B Normoxia Control Replicate 1 Hep3B Normoxia Control
- GSM9530240 Hep3B Normoxia Control Replicate 2 Hep3B Normoxia Control
- GSM9530241 Hep3B Normoxia Control Replicate 3 Hep3B Normoxia Control
- GSM9530242 JP7 Hypoxia TIFM Replicate 1 JP7 Hypoxia TIFM
- GSM9530243 JP7 Hypoxia TIFM Replicate 2 JP7 Hypoxia TIFM
- GSM9530244 JP7 Hypoxia TIFM Replicate 3 JP7 Hypoxia TIFM
- GSM9530245 JP7 Normoxia TIFM Replicate 1 JP7 Normoxia TIFM
- GSM9530246 JP7 Normoxia TIFM Replicate 2 JP7 Normoxia TIFM
- GSM9530247 JP7 Normoxia TIFM Replicate 3 JP7 Normoxia TIFM
- GSM9530248 JP8 Hypoxia TIFM Replicate 1 JP8 Hypoxia TIFM
- GSM9530249 JP8 Hypoxia TIFM Replicate 2 JP8 Hypoxia TIFM
- GSM9530250 JP8 Hypoxia TIFM Replicate 3 JP8 Hypoxia TIFM
- GSM9530251 JP8 Normoxia TIFM Replicate 1 JP8 Normoxia TIFM
- GSM9530252 JP8 Normoxia TIFM Replicate 2 JP8 Normoxia TIFM
- GSM9530253 JP8 Normoxia TIFM Replicate 3 JP8 Normoxia TIFM
- GSM9530254 MiaPaCa Hypoxia Control Replicate 1 MiaPaCa Hypoxia Control
- GSM9530255 MiaPaCa Hypoxia Control Replicate 2 MiaPaCa Hypoxia Control
- GSM9530256 MiaPaCa Hypoxia Control Replicate 3 MiaPaCa Hypoxia Control
- GSM9530257 MiaPaCa Hypoxia TIFM Replicate 1 MiaPaCa Hypoxia TIFM
- GSM9530258 MiaPaCa Hypoxia TIFM Replicate 2 MiaPaCa Hypoxia TIFM
- GSM9530259 MiaPaCa Hypoxia TIFM Replicate 3 MiaPaCa Hypoxia TIFM
- GSM9530260 MiaPaCa Normoxia Control Replicate 1 MiaPaCa Normoxia Control
- GSM9530261 MiaPaCa Normoxia Control Replicate 2 MiaPaCa Normoxia Control
- GSM9530262 MiaPaCa Normoxia Control Replicate 3 MiaPaCa Normoxia Control
- GSM9530263 MiaPaCa Normoxia TIFM Replicate 1 MiaPaCa Normoxia TIFM
- GSM9530264 MiaPaCa Normoxia TIFM Replicate 2 MiaPaCa Normoxia TIFM
- GSM9530265 MiaPaCa Normoxia TIFM Replicate 3 MiaPaCa Normoxia TIFM
- GSM9530266 Panc1 Hypoxia Control Replicate 1 Panc1 Hypoxia Control
- GSM9530267 Panc1 Hypoxia Control Replicate 2 Panc1 Hypoxia Control
- GSM9530268 Panc1 Hypoxia Control Replicate 3 Panc1 Hypoxia Control
- GSM9530269 Panc1 Hypoxia TIFM Replicate 1 Panc1 Hypoxia TIFM
+ 14 more — browse all 54 samples with per-sample file links →
- GSE150043 Deeper insight into Pancreatic Ductal Adenocarcinoma (PDAC) survival heterogeneity using integrative analyses of individual and global transcriptome based networks 19 samples same disease briefing · shares pdac, pancreatic
- GSE333988 Transcriptomic analysis of GKB202-treated circulating tumor cells isolated from patients with lung cancer and pancreatic cancer 10 samples same disease briefing · shares pancreatic
- GSE143584 Gene expression from laser capture microdissected epithelium and stroma during pancreatic carcinogenesis 366 samples same disease briefing · shares pancreatic
- GSE113616 Stromal Fibroblasts Drive Single Cell Heterogeneity in Pancreatic Cancer 189 samples same disease briefing · shares pancreatic
- GSE179351 Radiation Therapy Inhances Immunotherapy Response in Microsatellite-stable Colorectal and Pancreatic Adenocarcinoma in a Phase II Trial 54 samples same disease briefing · shares pancreatic
- GSE148188 NOXA dependent induction of apoptosis in pancreatic cancer cells 49 samples same disease briefing · shares pancreatic
- GSE101448 Microarray gene-expression data to identify a robust biomarker signature in PDAC and validate it in formalin-fixed paraffin-embedded tissue material. 43 samples same disease briefing · shares pdac
- GSE288221 RNA sequencing human melanoma, glioblastoma and pancreatic adenocarcinoma cell lines 32 samples same disease briefing · shares pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.