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The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of Adeno-Associated Virus Type 2 (wtAAV2) to cellular sites of DNA damage

GSE320210 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/02/25 Platform GPL18573
Summary
Using a modified iteration of a circular chromosome conformation capture to map the location of viral genomes (V3Cseq), we show that the Adeno-Associated Virus genome localizes spatially with cellular sites of DNA damage during treatment with DDR inhibitors or in the presence of a mutated KLF4 binding site within the wtAAV2 genome.
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The interaction between virus-bound KLF4 and host-bound PARP1 directs the localization of wild-type adeno-associated virus type 2 (wtAAV2) to cellular sites of DNA damage
Abrahams RR, Larsen CIS, Ha R et al. · Journal of virology 2026 · PMID 42053296 · doi:10.1128/jvi.00306-26
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Also filed as BioProject PRJNA1427158 and SRA study SRP678750. Searching any of these in the dataset finder brings you back here.

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