microRNA146a suppresses pancreatitis via cross-talk with NF-kB and ASC-containing inflammasomes
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE320220_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1427173 and SRA study SRP678771. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9537933 WT_PBS_1, WT pancreas, PBS, replicate 1
- GSM9537934 WT_PBS_2, WT pancreas, PBS, replicate 2
- GSM9537935 WT_PBS_3, WT pancreas, PBS, replicate 3
- GSM9537936 WT_PBS_4, WT pancreas, PBS, replicate 4
- GSM9537937 WT_PBS_5, WT pancreas, PBS, replicate 5
- GSM9537938 WT_Cer_1, WT pancreas, Cerulein, replicate 1
- GSM9537939 WT_Cer_2, WT pancreas, Cerulein, replicate 2
- GSM9537940 WT_Cer_3, WT pancreas, Cerulein, replicate 3
- GSM9537941 WT_Cer_4, WT pancreas, Cerulein, replicate 4
- GSM9537942 WT_Cer_5, WT pancreas, Cerulein, replicate 5
- GSM9537943 miR_PBS_1, miR146a KO pancreas, PBS, replicate 1
- GSM9537944 miR_PBS_2, miR146a KO pancreas, PBS, replicate 2
- GSM9537945 miR_PBS_3, miR146a KO pancreas, PBS, replicate 3
- GSM9537946 miR_PBS_4, miR146a KO pancreas, PBS, replicate 4
- GSM9537947 miR_PBS_5, miR146a KO pancreas, PBS, replicate 5
- GSM9537948 miR_Cer_1, miR146a KO pancreas, Cerulein, replicate 1
- GSM9537949 miR_Cer_2, miR146a KO pancreas, Cerulein, replicate 2
- GSM9537950 miR_Cer_3, miR146a KO pancreas, Cerulein, replicate 3
- GSM9537951 miR_Cer_4, miR146a KO pancreas, Cerulein, replicate 4
- GSM9537952 miR_Cer_5, miR146a KO pancreas, Cerulein, replicate 5
- GSE311286 Analysis of murine normal pancreatic organoids, pancreatitis-derived organoids, and PDAC organoids in complete media and of pancreatitis-derived organoids, and PDAC organoids cultured alone or cocultured with pancreatic stellate cells in reduced media 75 samples shares pancreatitis
- GSE260762 Deletion of CD177 exacerbates acute pancreatitis-associated lung injury and colonic barrier dysfunction in a mouse model of acute pancreatitis 39 samples shares pancreatitis
- GSE297476 Lactate facilitates pancreatic repair following acute pancreatitis by promoting reparative macrophage polarization 28 samples shares pancreatitis
- GSE248106 Roquin-deficient T cells drive pancreatitis and tumorigenesis through IL-17 and Th17-inappropriate Cytokine production 21 samples shares pancreatitis
- GSE285771 Orai1 in pancreatic ductal cells mediates pancreas-intestinal crosstalk in experimental acute pancreatitis via the secretion of antimicrobial peptide REG3B in pancreatic juice 18 samples shares pancreatitis
- GSE261286 Deconstructing synthetic inflammasomes in tumors drives diverse antitumor responses 18 samples shares inflammasomes
- GSE169525 Inactivation of the Euchromatic Histone-lysine N-methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks 17 samples shares pancreatitis
- GSE277452 Effects of tofacitinib and takinib on autoimmune pancreatitis in mice 14 samples shares pancreatitis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.