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USP18 inhibits protective immune responses and the intracellular control of Mycobacterium tuberculosis in macrophages.

GSE320445 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2026/03/02 Platform GPL13112
Summary
We compared the transcriptome profile of M. tuberculosis-infected murine bone marrow derived macrophages (BMM) treated with either the USP18 small molecule inhibitor BB7 or an inactive control (NC), and uninfected controls as described below. We identified 710 differentially expressed genes (DEGs) between uninfected and Mtb BMM and 243 DEGs comparing Mtb-BB7 vs Mtb BMM, 129 of these DEGs were upregulated. Gene ontology (GO) analysis showed enrichment of pathways related to antiviral responses, innate immune activation and inflammasome signalling when comparing Mtb-BB7 vs Mtb BMM. Conversely, genes associated with stress responses, hypoxia and antioxidant activity were downregulated in Mtb-BB7.
Published in
Pharmacological inhibition of USP18 improves antibacterial responses and the intracellular control of Mycobacterium tuberculosis in macrophages
Zhang Q, Gong Z, Schnell R et al. · Frontiers in immunology 2026 · PMID 41859120 · doi:10.3389/fimmu.2026.1739628
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Also filed as BioProject PRJNA1428221 and SRA study SRP679288. Searching any of these in the dataset finder brings you back here.

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