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Transcriptomic profiling of HaCaT cells after 24-hour exposure to Fusobacterium nucleatum-derived outer membrane vesicles

GSE320506 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/15 Platform GPL34284
Summary
Fusobacterium nucleatum is an anaerobic Gram-negative bacterium implicated in mucosal inflammatory conditions. Outer membrane vesicles (OMVs) derived from Gram-negative bacteria are recognized as important mediators of host–microbe interactions. In this study, bulk RNA sequencing was performed to investigate global gene expression changes in HaCaT human keratinocytes following 24-hour treatment with F.n-OMVs (10 μg/mL). The dataset provides transcriptomic profiles of treated and untreated cells and serves as a resource for exploring host cellular responses to bacterial vesicles.
Published in
Fusobacterium nucleatum-Derived Outer Membrane Vesicles Disrupt Epithelial Barrier in Oral Lichen Planus via JNK/c-JUN Mediated Claudin-4 Downregulation
Shao R, Wang Z, Yang C et al. · International dental journal 2026 · PMID 42048970 · doi:10.1016/j.identj.2026.109526
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Direct links to NCBI, no account and no request form: the whole study as GSE320506_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1428736 and SRA study SRP679482. Searching any of these in the dataset finder brings you back here.

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