Alyref Deficiency Exacerbates Chronic Inflammatory Pain by Impairing m5C-Dependent Nuclear Export of Ccn3 mRNA
RNA-seq (gene expression) · mouse · 8 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 8 samples: 4 × mouse-DRG-WT vs 4 × mouse-DRG-cKOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Alyref Deficiency Exacerbates Chronic Inflammatory Pain by Impairing Nuclear Export of Ccn3 MRNAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE321975_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1429351 and SRA study SRP679840. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 8 samples.
How we read this: 2 replicated groups read from 8 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9550769 mouse-DRG-WT-rep1 mouse-DRG-WT
- GSM9550770 mouse-DRG-WT-rep2 mouse-DRG-WT
- GSM9550771 mouse-DRG-WT-rep3 mouse-DRG-WT
- GSM9550772 mouse-DRG-WT-rep4 mouse-DRG-WT
- GSM9550773 mouse-DRG-cKO-rep1 mouse-DRG-cKO
- GSM9550774 mouse-DRG-cKO-rep2 mouse-DRG-cKO
- GSM9550775 mouse-DRG-cKO-rep3 mouse-DRG-cKO
- GSM9550776 mouse-DRG-cKO-rep4 mouse-DRG-cKO
- GSE281404 Deficiency of the palmitoyl acyltransferase ZDHHC7 modulates gene expression in mice after a mild chronic stress paradigm 80 samples shares deficiency, chronic
- GSE317833 PD-1 Deficiency Exacerbates Mycobacterium abscessus Lung Infection via Dysregulated T Cell Responses 30 samples shares exacerbates, deficiency
- GSE255744 Se Deficiency Exacerbates Hyperoxia-Induced Lung Injury in Newborn C3H/HeN Mice 24 samples shares exacerbates, deficiency
- GSE249926 Chronic Stress Exacerbates Cerebral Amyloid Angiopathy through Promoting NET formation 12 samples shares exacerbates, chronic
- GSE248879 Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females [liver] 16 samples shares ccn3
- GSE243060 Multi-organ Transcriptome Atlas of a Mouse Model of Relative Energy Deficiency in Sport (REDs) 419 samples shares deficiency
- GSE254229 ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice 141 samples shares deficiency
- GSE267786 Impact of SLC15A4, TASL and TASL2(Gm6377) deficiency on endolysosomal TLR7 and TLR9 responses 95 samples shares deficiency
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.