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Gene expression in synovial membranes from patients with early and end-stage osteoarthritis

GSE32317 Homo sapiens Expression profiling by array; Third-party reanalysis 19 samples Submitted 2011/11/01 Platform GPL570
Summary
Osteoarthritis is characterized by degeneration of cartilage and bone in the synovial joints. Recent findings suggest that inflammation may play a role in osteoarthritis, with synovitis being associated with the clinical symptoms of osteoarthritis. Furthermore, we have found that levels of inflammatory complement components are abnormally high in the synovial fluid of individuals with osteoarthritis. To determine whether synovial membranes could be a source of complement and other inflammatory molecules in osteoarthritic joints, we characterized the expression of genes in synovial membranes from patients with early-stage or end-stage osteoarthritis.
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Also filed as BioProject PRJNA147293. Searching any of these in the dataset finder brings you back here.

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