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Human SW480 cells: Untreated vs H2O2 Treated

GSE32382 Homo sapiens Genome binding/occupancy profiling by genome tiling array 38 samples Submitted 2011/12/01 Platform GPL14622Platform GPL8170Platform GPL14618Platform GPL8169
Summary
ChIP-on-chip tilling array comparing untreated human SW480 cells vs SW480 cells treated with 2mM H2O2 for 30min. Exposing cells to the reactive oxygen species, hydrogen peroxide, recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin. DNMT1 becomes part of a complex(es) containing DNMT3B and members of Polycomb Repressive Complex 4. The goal was to determine the effect of hydrogen peroxide treatment on chromatin, including changes in histone modifications and binding patterns of chromatin-associated proteins.
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Also filed as BioProject PRJNA147959. Searching any of these in the dataset finder brings you back here.

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