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Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton

GSE324124 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/05/11 Platform GPL34281
Summary
Growth factors selectively activate calcium signaling pathways in the cell nucleus, which in turn regulate gene transcription and other intra-nuclear events, but the specific way this is accomplished is not entirely understood. The present study shows that growth factors increase inositol 1,4,5-trisphosphate (IP3) in the nucleus, which in turn releases calcium from intranuclear IP3 receptors (ITPRs), which then leads to transient assembly of an actin nucleoskeleton that associates with intranuclear MYH9. Mass spectrometry suggests that much of the MYH9 cargo consists of components of the gene transcription machinery, while chromatin immunoprecipitation identified a number of specific genes that associate with the myosin in response to stimulation with growth factors. Together, these findings suggest that growth factors initiate gene transcription by transiently assembling an actin nucleoskeleton that works with MYH9 to bring specific genes to the transcription machinery.
Published in
Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton
González MJ, Rodrigues MA, Diprima S et al. · The Journal of biological chemistry 2026 · PMID 42103234 · doi:10.1016/j.jbc.2026.113104
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Also filed as BioProject PRJNA1433478 and SRA study SRP681749. Searching any of these in the dataset finder brings you back here.

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