GEO series
Transcriptomic analysis of Primary B-cell target genes upon infection with Epstein-Barr Virus (EBV) expressing wildtype (WT) or mutant Latent Membrane Protein 1 (LMP1)
GSE324842
Homo sapiens
Expression profiling by high throughput sequencing
25 samples
2026/03/18
GPL18573
Summary
RNA-seq was used to characterize the LMP1 mediated regulation of host B-cell gene regulation. We infected Primary B-cells with Bacterial Artificial Chromosome (BAC)-derived WT LMP1 or TES1 mutant or TES2 mutant or TES1/TES2 double mutant LMP1 expressing EBV. Samples were assessed for transcriptomics effect on the host B-cell landscape at D7 post-infection and D21 post-infection.Because the TES1m and DM infected B-cells donot survive past D21 post-infection, D21 samples included WT vs TES2minfected B-cells only.
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