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Targeting branched-chain amino acids alleviates pulmonary fibrosis

GSE325209 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/03/18 Platform GPL34290
Summary
Purpose: To determine whether BCAAs regulate H3K36me3 modification on collagen genes via KDM4A. Methods: We transfected two KDM4A siRNAs into MLF cells. After 24 h of transfection, the cells were treated with 20 ng/mL TGF-β1 for 48 h, followed by CUT&Tag assay for H3K36me3. Conclusions: BCAAs promote H3K36me3 modification on collagen genes via KDM4A.
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Also filed as BioProject PRJNA1439178 and SRA study SRP684739. Searching any of these in the dataset finder brings you back here.

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