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Bile acids mediate liver-bone marrow crosstalk

GSE325236 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2026/04/12 Platform GPL24247
Summary
This study examines the impact of tumor presence on bone marrow hematopoiesis in mouse models of liver cancer. Using a Hepa1-6 xenograft model in C57BL/6 mice, hematopoietic stem and progenitor cell populations were analyzed by flow cytometry. Although overall HSPC frequencies did not differ between tumor-bearing and control mice, tumor size positively correlated with HSPC numbers. RNA-seq comparison between xenograft and DEN-induced liver tumors revealed distinct transcriptomic profiles, indicating that xenograft tumors do not fully recapitulate the liver tumor microenvironment.
Published in
Bile acids mediate liver-bone marrow crosstalk
Vitale D, Azardaryany MK, Alipour Talesh G et al. · iScience 2026 · PMID 42389593 · doi:10.1016/j.isci.2026.116462
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Direct links to NCBI, no account and no request form: the whole study as GSE325236_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1439240 and SRA study SRP684791. Searching any of these in the dataset finder brings you back here.

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