Targeting EHMT2 Enhances NK Cell Maturation and Antitumor Activity [RNA-Seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × NK92MI, BIX-01294 treated vs 3 × NK92MI, DMSO treated vs 3 × NK cell, Wild-type vs 3 × NK cell, EHMT2-KOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE325753_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1441560 and SRA study SRP686009. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 3 samples read as cases, 3 as controls.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9612549 NK92MI, BIX-01294 treated rep1 NK92MI, BIX-01294 treat…
- GSM9612550 NK92MI, BIX-01294 treated rep2 NK92MI, BIX-01294 treat…
- GSM9612551 NK92MI, BIX-01294 treated rep3 NK92MI, BIX-01294 treat…
- GSM9612552 NK92MI, DMSO treated rep1 NK92MI, DMSO treated
- GSM9612553 NK92MI, DMSO treated rep2 NK92MI, DMSO treated
- GSM9612554 NK92MI, DMSO treated rep3 NK92MI, DMSO treated
- GSM9612555 NK cell, Wild-type rep1 NK cell, Wild-type
- GSM9612556 NK cell, Wild-type rep2 NK cell, Wild-type
- GSM9612557 NK cell, Wild-type rep3 NK cell, Wild-type
- GSM9612558 NK cell, EHMT2-KO rep1 NK cell, EHMT2-KO
- GSM9612559 NK cell, EHMT2-KO rep2 NK cell, EHMT2-KO
- GSM9612560 NK cell, EHMT2-KO rep3 NK cell, EHMT2-KO
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.