Integrated Transcriptomic Profiling Reveals Immune and Molecular Stage-Specific Signatures of Colorectal Cancer in Hispanics Living in Puerto Rico

Colorectal Cancer (CRC) has become the second leading cause of death related to cancer worldwide and the third most common malignancy. CRC tumors are classified into stages to describe the cancer; early (stages I and II) and advanced (stages III and IV). Despite the available screening methods and the scientific efforts in the development of a universal biomarker pannel for CRC early detection, there still exists a gap in a reliable non-invasive screening method for the Hispanic community. We aimed to elucidate the most important pathways along with the differential gene expression in early and advanced CRC stages in Hispanics living in Puerto Rico (PRH).