Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis [H3K27ac_CUT&RUN]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 8 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 8 samples: 3 × Gata6KO_H3K27ac vs 3 × Control_H3K27acGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE326232_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1444173 and SRA study SRP687269. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 2 replicated groups read from 8 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9625625 Gata6KO_H3K27ac_replicate1 Gata6KO_H3K27ac
- GSM9625626 Gata6KO_H3K27ac_replicate2 Gata6KO_H3K27ac
- GSM9625627 Gata6KO_H3K27ac_replicate3 Gata6KO_H3K27ac
- GSM9625628 Control_H3K27ac_replicate1 Control_H3K27ac
- GSM9625629 Control_H3K27ac_replicate2 Control_H3K27ac
- GSM9625630 Control_H3K27ac_replicate3 Control_H3K27ac
- GSM9625631 Control_H3K4me3_positive_control
- GSM9625632 Control_IgG_negative_control
- GSE290756 Lineage Plasticity Driven by GATA6 Loss Fuels Colorectal Cancer Metastasis 50 samples shares gata6, plasticity, colorectal, metastasis, lineage
- GSE294107 CUT&RUN sequencing - E12 mouse embryonic cortices ZBTB7A - GATAD2B - H3K27ac… 18 samples shares h3k27ac, cut, run
- GSE306261 Astrocyte glucocorticoid receptor signaling restricts neuronal plasticity [CUT&RUN] 50 samples shares cut, run, plasticity
- GSE298002 Stage-specific Epigenetic Priming Amplifies Gene Activation During Lineage Commitment [CUT&Run] 38 samples shares cut, run, lineage
- GSE289642 Noncanonical PRC2 chromatin association reveals a key role of EZHIP in intergenerational epigenetic memory transition [ChIP-Seq, Cut & Run] 107 samples shares cut, run
- GSE303384 Mechanism of maintenance and establishment of repression by the Mtg16 tumor suppressor [CUT&RUN, ChIP-Seq] 92 samples shares cut, run
- GSE313359 Hippocampal estrogen levels, receptor types and epigenetics contribute to sex-specific memory-vulnerabilities to concurrent acute stresses [Cut & Run] 45 samples shares cut, run
- GSE292333 H2AK119ub1-MLL2 counteraction underlies heritable H3K27me3 formation in oocytes [CATCH-seq and CUT&RUN] 44 samples shares cut, run
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.