Multimodal profiling reveals a Notch-responsive regenerative subpopulation of cochlear supporting cells
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 22 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 4 × P0_CompE vs 4 × P0_DMSO vs 3 × P6_CompE vs 3 × P6_DMSOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Live imaging and multimodal profiling reveal transdifferentiation of a cochlear supporting cell subpopulation upon Notch inhibitionScience advances · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327017_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1449014 and SRA study SRP655369. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 4 samples read as cases, 11 as controls.
How we read this: 4 replicated groups read from 22 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9308800 DMSO Control scMultiome replicate #1 RNA library
- GSM9308801 DMSO Control scMultiome replicate #1 ATAC library
- GSM9308802 DMSO Control scMultiome replicate #2 RNA library
- GSM9308803 DMSO Control scMultiome replicate #2 ATAC library
- GSM9308804 CompE-treated scMultiome replicate #1 RNA library
- GSM9308805 CompE-treated scMultiome replicate #1ATAC library
- GSM9308806 CompE-treated scMultiome replicate #2 RNA library
- GSM9308807 CompE-treated scMultiome replicate #2 ATAC library
- GSM9377016 P0_CompE_rep1 P0_CompE
- GSM9377017 P0_CompE_rep2 P0_CompE
- GSM9377018 P0_CompE_rep3 P0_CompE
- GSM9377019 P0_CompE_rep4 P0_CompE
- GSM9377020 P0_DMSO_rep1 P0_DMSO
- GSM9377021 P0_DMSO_rep2 P0_DMSO
- GSM9377022 P0_DMSO_rep3 P0_DMSO
- GSM9377023 P0_DMSO_rep4 P0_DMSO
- GSM9377024 P6_CompE_rep1 P6_CompE
- GSM9377025 P6_CompE_rep2 P6_CompE
- GSM9377026 P6_CompE_rep3 P6_CompE
- GSM9377027 P6_DMSO_rep1 P6_DMSO
- GSM9377028 P6_DMSO_rep2 P6_DMSO
- GSM9377029 P6_DMSO_rep3 P6_DMSO
- GSE313875 Multimodal profiling reveals a Notch-responsive regenerative subpopulation of cochlear supporting cells [2] 14 samples shares notch-responsive, subpopulation, regenerative, multimodal, supporting, cochlear
- GSE205411 Multiple subpopulations in medullary thymic epithelial cells are regulated by Aire with distinctive modes of gene regulations 2219 samples shares subpopulation
- GSE205991 Multiple subpopulations in medullary thymic epithelial cells are regulated by Aire with distinctive modes of gene regulations [deep single-cell RNA-seq] 2148 samples shares subpopulation
- GSE72826 Gene expression profiling of cell subpopulations from different regions of the mouse brain 36 samples shares subpopulation
- GSE273792 Multimodal single cell profiling of bone fracture microenvironment 24 samples shares multimodal
- GSE246779 Single-cell multimodal profiling of atherosclerosis identifies CD200 as a cell surface lineage marker of vascular smooth muscle cells and their derived cells 24 samples shares multimodal
- GSE326118 Multimodal Single-Cell Transcriptomic and Chromatin Accessibility Profiling Reveals Monocyte-Derived Macrophage Dynamics Following Ischemic Stroke [scATAC-seq] 2 samples shares multimodal
- GSE232746 The GPR84 molecule is a mediator of a subpopulation of retinal microglia that promote TNF/IL-1α expression via the rho-ROCK pathway after optic nerve injury II 144 samples shares subpopulation
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.