Motif-directed chromatin repression by BCL11B shapes ectopic targeting and lineage commitment
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 76 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 76 samples: 64 distinct titles, 12 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327367_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1450581 and SRA study SRP690171. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 76 sample titles: 64 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9624168 CD34, empty vector, IgG
- GSM9624170 CD34, empty vector, HA, rep1
- GSM9624172 CD34, empty vector, HA, rep2
- GSM9624174 CD34, empty vector, HA, merged
- GSM9624176 CD34, BCL11B-dTAG, IgG
- GSM9624178 CD34, BCL11B-dTAG, HA, rep1
- GSM9624180 CD34, BCL11B-dTAG, HA, rep2
- GSM9624182 CD34, BCL11B-dTAG, HA, merged
- GSM9624184 CD34, empty vector, RUNX1, rep1
- GSM9624186 CD34, empty vector, RUNX1, rep2
- GSM9624188 CD34, empty vector, RUNX1, merged
- GSM9624190 CD34, BCL11B-dTAG, RUNX1, rep1
- GSM9624192 CD34, BCL11B-dTAG, RUNX1, rep2
- GSM9624194 CD34, BCL11B-dTAG, RUNX1, merged
- GSM9624196 CD34, empty vector, RUNX1, DMSO, rep1
- GSM9624198 CD34, empty vector, RUNX1, DMSO, rep2
- GSM9624200 CD34, empty vector, RUNX1, dTAGV-1, rep1
- GSM9624202 CD34, empty vector, RUNX1, dTAGV-1, rep2
- GSM9624204 CD34, BCL11B-dTAG, RUNX1, DMSO, rep1
- GSM9624206 CD34, BCL11B-dTAG, RUNX1, DMSO, rep2
- GSM9624208 CD34, BCL11B-dTAG, RUNX1, dTAGV-1, rep1
- GSM9624209 CD34, BCL11B-dTAG, RUNX1, dTAGV-1, rep2
- GSM9624210 CD34-018, empty vector, RUNX1
- GSM9624211 CD34-018, empty vector, IgG
- GSM9624212 CD34-018, BCL11B, RUNX1
- GSM9624213 CD34-018, BCL11B, IgG
- GSM9624214 CD34-018, BCL11B-dTAG, RUNX1
- GSM9624215 CD34-018, BCL11B-dTAG, IgG
- GSM9624216 CD34-016, empty vector, IgG
- GSM9624217 CD34-016, empty vector, BRG1, DMSO, rep1
- GSM9624218 CD34-016, empty vector, BRG1, DMSO, rep2
- GSM9624219 CD34-016, empty vector, BRG1, dTAGV-1, rep1
- GSM9624220 CD34-016, empty vector, BRG1, dTAGV-1, rep2
- GSM9624221 CD34-016, BCL11B-dTAG, IgG
- GSM9624222 CD34-016, BCL11B-dTAG, BRG1, DMSO, rep1
- GSM9624223 CD34-016, BCL11B-dTAG, BRG1, DMSO, rep2
- GSM9624224 CD34-016, BCL11B-dTAG, BRG1, dTAGV-1, rep1
- GSM9624225 CD34-016, BCL11B-dTAG, BRG1, dTAGV-1, rep2
- GSM9624226 Jurkat, BCL11B-dTAG, IgG
- GSM9624227 Jurkat, BCL11B-dTAG, HA
+ 36 more — browse all 76 samples with per-sample file links →
- GSE327360 Motif-directed chromatin repression by BCL11B shapes ectopic targeting and lineage commitment [ATAC-seq] 20 samples shares bcl11b, motif-directed, repression, commitment, chromatin, targeting, ectopic, lineage
- GSE327361 Motif-directed chromatin repression by BCL11B shapes ectopic targeting and lineage commitment [RNA-seq] 16 samples shares bcl11b, motif-directed, repression, commitment, chromatin, targeting, ectopic, lineage
- GSE323137 Targeting the CHD3 Chromatin Remodeler Exploits a Synthetic Lethal Vulnerability in SWI/SNF-Deficient Cancers via Toxic Derepression of PARD3B 39 samples shares repression, chromatin, targeting
- GSE300907 Extensive enhancer crosstalk governs the induction of PPARG2 expression during adipogenic lineage commitment 120 samples shares commitment, lineage
- GSE254244 Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes 112 samples shares repression, chromatin
- GSE254242 Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes [RNA-Seq] 99 samples shares repression, chromatin
- GSE267992 Mutant GFAP alters lineage commitment of neural organoids 79 samples shares commitment, lineage
- GSE300899 Extensive enhancer crosstalk governs the induction of PPARG2 expression during adipogenic lineage commitment [Chip-Seq] 76 samples shares commitment, lineage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.