Dermal fibroblasts attenuate osteoarthritis by restoring synovial fibroblast homeostasis
Single-cell RNA-seq · mouse · 9 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 9 samples: 3 × scRNA-seq of P vs 3 × scRNA-seq of D vs 3 × scRNA-seq of CGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dermal fibroblasts attenuate osteoarthritis by restoring synovial fibroblast homeostasisJournal of orthopaedic translation · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE327818_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1452836 and SRA study SRP691420. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 9 samples.
How we read this: 3 replicated groups read from 9 sample titles; they account for 9 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9666487 scRNA-seq of P1 scRNA-seq of P
- GSM9666488 scRNA-seq of P2 scRNA-seq of P
- GSM9666489 scRNA-seq of P3 scRNA-seq of P
- GSM9666490 scRNA-seq of D1 scRNA-seq of D
- GSM9666491 scRNA-seq of D2 scRNA-seq of D
- GSM9666492 scRNA-seq of D3 scRNA-seq of D
- GSM9666493 scRNA-seq of C1 scRNA-seq of C
- GSM9666494 scRNA-seq of C2 scRNA-seq of C
- GSM9666495 scRNA-seq of C3 scRNA-seq of C
- GSE307681 Dermal fibroblasts respond to interleukin-4 and 13 and promote T-cell recruitment in atopic dermatitis 12 samples shares fibroblasts, fibroblast, dermal
- GSE274992 Splenic fibroblasts control marginal zone B-cell movement and function via two distinct Notch2-dependent regulatory programs 119 samples shares fibroblasts, fibroblast
- GSE182731 Inhibition of ATM in Mouse-derived lung fibroblasts 27 samples shares fibroblasts, fibroblast
- GSE279927 RNA next-generation sequencing of cardiac fibroblasts isolated from young and old mice 7 days post-MI 25 samples shares fibroblasts, fibroblast
- GSE284808 Bulk RNAseq of sorted fibroblasts from a mouse model of stretch-mediated skin expansion 22 samples shares fibroblasts, fibroblast
- GSE262420 Mechanomemory of pulmonary fibroblasts demonstrates reversibility of transcriptomics and contraction phenotypes 20 samples shares fibroblasts, fibroblast
- GSE266899 The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen hydroxyprolination and favoring immune infiltration. 18 samples shares fibroblasts, fibroblast
- GSE267256 Bulk RNA-seq analysis reveals the crucial role of Collagen triplex helix repeat containing-1 (Cthrc1) cardiac fibroblasts for ventricular remodeling after myocardial infarction 17 samples shares fibroblasts, fibroblast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.