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Single-cell RNA sequencing reveals that Epac1 deletion attenuates Müller glial pathological activation in ischemia-induced retinopathy

GSE328096 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/04/15 Platform GPL19057
Summary
Here we report the single-cell RNA sequencing (scRNA-seq) analysis of retinas from WT and Epac1-knockout mice under Oxygen-Induced Retinopathy (OIR) and Room Air (RA) conditions. The OIR model was induced by exposing pups to 70% oxygen from postnatal day 7 (P7) to P12. This study aims to delineate the cellular heterogeneity and investigate the neuroprotective mechanisms associated with Epac1 deletion, with a specific focus on Müller glial pathological activation and retinal neurodegeneration. Retinal tissues were collected at postnatal day 17 (P17) to establish a comprehensive transcriptomic profile of the ischemia-induced retinopathy model.
Published in
Epac1 deletion attenuates Müller glial pathological activation and mitigates retinal neurodegeneration in ischemia-induced retinopathy
Shi S, Xia F, Lu Z et al. · Journal of advanced research 2026 · PMID 40976555 · doi:10.1016/j.jare.2025.09.031
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Also filed as BioProject PRJNA1453907 and SRA study SRP692063. Searching any of these in the dataset finder brings you back here.

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