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Single-cell transcriptomic analysis of SP11-treated DLA lymphoma mouse model

GSE328097 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/07/01 Platform GPL24247
Summary
We used single-cell RNA sequencing with the 10x Genomics platform to study the effect of SP11 treatment in a DLA lymphoma mouse model. The goal was to examine tumor heterogeneity, identify potential treatment-resistant cell populations, and assess changes in the tumor microenvironment and immune cell infiltration. This dataset provides an overview of how SP11 impacts tumor biology at single-cell resolution.
Published in
Single-Cell Transcriptomic Profiling Reveals Dual Antitumor and Adaptive Resistance Mechanisms of a Novel HSP90 Inhibitor, SP11, in T-Cell Acute Lymphoblastic Leukemic Cells and DLA Mouse Model
M V S, R A, Choudhary B · International journal of molecular sciences 2026 · PMID 42353040 · doi:10.3390/ijms27125321
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Direct links to NCBI, no account and no request form: the whole study as GSE328097_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1453909 and SRA study SRP692064. Searching any of these in the dataset finder brings you back here.

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