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Adipose Derived Reprogrammed iMSCs Exhibit Enhanced Therapeutic Potential for Treating Skin Fibrosis

GSE328274 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/06/01 Platform GPL24676
Summary
Localized scleroderma (LoS) is a fibrotic skin disorder characterized by excessive collagen deposition, leading to functional and cosmetic impairments. Mesenchymal stromal cells (MSCs) offer therapeutic potential through immunomodulation and tissue repair, but their clinical use is limited by donor variability and replicative senescence. Induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) present a promising alternative owing to their scalable production and rejuvenated phenotype.
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Direct links to NCBI, no account and no request form: the whole study as GSE328274_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1454461 and SRA study SRP692443. Searching any of these in the dataset finder brings you back here.

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