GEO series
Identification of two genes associated with recurrence in Paget’s disease and construction of a predictive model
GSE328302
Homo sapiens
Expression profiling by high throughput sequencing
39 samples
2026/04/21
GPL20301
Summary
In summary, RNA‑seq analysis revealed distinct functional profiles between MPD and EMPD, with recurrence in MPD associated with developmental and differentiation pathways, while EMPD recurrence was linked to immune and inflammatory processes. Using WGCNA, we identified KLF13 and TIA1 as hub genes, which were subsequently validated as independent prognostic biomarkers in internal and external datasets. A risk‑score model based on these genes effectively stratified patients by outcome. Further studies are needed to elucidate the detailed molecular mechanisms underlying their roles in PD progression and recurrence.
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