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Investigation of the Effect and Target of SchA in the Treatment of Triple-Negative Breast Cancer

GSE328358 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2026/06/11 Platform GPL29480
Summary
SchA, one of the key bioactive components derived from Schisandra chinensis, was found in our study to exert a significant inhibitory effect on breast cancer cell viability. To elucidate the underlying mechanism, we integrated bioinformatics analysis with network pharmacology approaches to predict potential targets of SchA. The findings suggest that SchA may exert its anti-tumor effects by modulating IDO1 (indoleamine 2,3-dioxygenase 1), providing a foundation for further mechanistic investigation.
Published in
Integrated Network Pharmacology and Machine Learning to Reveal the Mechanisms of Schisandrin A Against Triple-Negative Breast Cancer
Xu M, Zhang Y, Mei R et al. · Journal of cellular and molecular medicine 2026 · PMID 42220063 · doi:10.1111/jcmm.71219
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Also filed as BioProject PRJNA1454833 and SRA study SRP692712. Searching any of these in the dataset finder brings you back here.

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