GEO series
Gene expression profiling of A498 clear cell renal cell carcinoma cells following HIF1A and HIF2A knockdown
GSE328454
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/07/20
GPL24676
Summary
This dataset investigates hypoxia-associated transcriptional regulation in clear cell renal cell carcinoma. Following the identification of hypoxia-related gene programs in malignant cells, siRNA-mediated knockdown of HIF1A, HIF2A, or both was performed in A498 cells. RNA sequencing and differential gene expression analysis were used to identify gene signatures specifically regulated by HIF1A or HIF2A.
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