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A regulatory TRIF/IL-1R1 axis controls T-dependent IgA production in the intestines

GSE328882 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/06/01 Platform GPL34290
Summary
This study investigates the innate signals that constrain intestinal IgA induction. Using single-cell RNA sequencing (scRNA-seq), we profiled the Peyer's patch immune landscape in wild-type, Trif-/-, and Il1r1-/- mice. Our analysis reveals that TRIF and IL-1R1 act as molecular "brakes" on mucosal humoral immunity. The dataset provides a high-resolution map of how TRIF and IL-1R1 modulate the B cell microenvironment and intrinsic differentiation pathways to limit mucosal IgA responses.
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Direct links to NCBI, no account and no request form: the whole study as GSE328882_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1456951 and SRA study SRP694195. Searching any of these in the dataset finder brings you back here.

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